经常发生的带脱:个性化治疗或手术治疗? 随机试验的REPORT随机试验协议
Susanne Arnold1, Aminul Haque1, Manjit Aujla1
1Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.
BMJ open
|August 22, 2024
概括
这项研究比较了个性化膝关节治疗与治疗复发型关节脱的手术. 它旨在确定对年轻成年人这种衰弱状况的最有效治疗方法.
科学领域:
- 整形外科 整形外科 整形外科
- 运动医学 运动医学
- 康复科学 康复科学 康复科学
背景情况:
- 经常发生的带脱位通常影响年轻人,导致疼痛和潜在的长期损伤,如骨关节炎.
- 目前的治疗方案包括物理治疗和手术,但其相对有效性尚不清楚.
研究的目的:
- 为了比较个性化膝关节疗法的临床效果和成本效益,与复发型膝关节脱手术相比.
- 评估哪种初始管理策略能为患者带来更好的结果.
主要方法:
- 一个务实,多中心,双臂,优越性,随机对照试验 (REPPORT) 涉及276名参与者.
- 参与者被随机分配1:1个性化膝关节治疗或手术,按年龄分层,关节高和招募地点.
- 主要结局是参与者报告的功能 (膝盖损伤和骨关节炎结局4域得分) 在18个月;包括健康经济评估.
主要成果:
- 在随机化后18个月收集初级结果数据.
- 二次结果包括不稳定性,健康实用性和不良事件,收集到24个月.
- 分析将是治疗的意图.
结论:
- 该REPPORT试验将提供关键的证据,以最佳的管理策略反复发生的带脱.
- 结果将为临床决策提供信息,并可能指导未来的治疗指南.
- 结果将通过出版物,会议和在线道传播.
更多相关视频
05:07Author Spotlight: Implementing the Enhanced Recovery After Surgery Concept in Rehabilitation Following Anterior Cruciate Ligament Reconstruction
Published on: March 1, 2024
1.6K
03:26Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
Published on: March 8, 2024
2.5K
相关概念视频
Group Design
The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between the two are due to...
Blind Procedures
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Randomized Experiments
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Simple randomization
Simple...
Blinding
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
Self-Report Tests of Personality
Self-report inventories are objective personality assessments that use multiple-choice items or numbered scales, typically ranging from 1 (strongly disagree) to 5 (strongly agree). They are often called Likert scales after Rensis Likert. These inventories are widely used due to their ease of administration and cost-effectiveness. One of the most prominent examples is the Minnesota Multiphasic Personality Inventory (MMPI), initially developed in the 1940s to assess abnormal personality traits.
Psychosurgery
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
