多变量时间序列方法从潜在患者收集的日记数据中提取预测性喘生物标志物:系统性审查
Franz Aaron Apritado Clemeno1, Eleanor Quek2, Matthew Richardson1
1Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester College of Life Sciences, Leicester, UK.
BMJ open
|August 22, 2024
概括
患者日记数据可以预测喘恶化和控制不良. 峰值呼气流和症状的变化表明结果更差,但预测模型的报告需要改进,以更好地管理喘.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 生物标志物发现发现
- 在医疗保健中的数据科学.
背景情况:
- 纵向数据对于理解喘进展和预测未来的事件,如恶化和控制至关重要.
- 患者收集的日记变量为生物标志物提取提供了丰富的时间数据来源.
研究的目的:
- 系统地审查从纵向喘日记数据中提取生物标志物的方法.
- 调查这些生物标志物与患者报告结果 (PROs) 之间的关联.
主要方法:
- 2000年1月至2023年7月期间发表的研究的系统审查和叙事综合.
- 包括研究产生生物标志物从峰值呼气流,症状得分,缓解剂的使用,和夜间觉醒.
- 使用TRIPOD和PROBAST工具评估研究质量和偏差风险.
主要成果:
- 日常变量的更高变化与喘恶化风险增加和喘控制较差相关.
- 对分析复杂日记数据的非参数方法越来越感兴趣.
- 在包含的研究中发现的模型性能和潜在偏差的不一致报告.
结论:
- 患者收集的日记数据可以产生有价值的喘评估工具和预测生物标志物.
- 缺乏对模型性能进行强有力的报告,这需要未来的研究改进.
- 每日变量衍生的生物标志物对远程监测和临床试验终点具有前景.
相关概念视频
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
254
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
254
Asthma: Pathogenesis and Management
376
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
376


