红细胞覆盖下的药物输送延长了药物的半衰期:使用微环境响应的人工多糖微粒的血栓消毒向治疗
Lianqi Shan1, Junsu Wang2, Hongyu Tu2
1State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.
Carbohydrate polymers
|August 22, 2024
概括
研究人员开发了用于向血栓溶解的新型微微囊药载体. 这些载体通过粘附于红细胞来延长尿素酶类型等离子素激活剂 (uPA) 半衰期,改善血栓向和药物输送以预防复发性血栓形成.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 心血管研究研究心血管研究
背景情况:
- 开发有效的血栓溶解药物载体是一项挑战.
- 现有的载体往往缺乏有针对性的交付,长期循环和受控释放.
- 抑制血栓复发需要先进的治疗策略.
研究的目的:
- 构建和评估用于血栓溶解的人工多糖微粒药物递送系统 (uPA-CS/HS@RGD-ODE).
- 评估载体对血栓向,延长血液循环和响应性药物释放的能力.
- 调查红细胞覆盖分娩延长药物半衰期的潜力.
主要方法:
- 基托和肝素层层地组合在一起,形成微小.
- 用RGD和2-(N-氧化物-N,N-二甲基氨酸) 乙烯基甲酸盐 (ODE) 进行表面修饰.
- 尿激酶类型等离子体激活剂 (uPA) 的封装和体外/体内评估.
主要成果:
- uPA载体 (CS/HS@RGD-ODE) 显示出对激活血小板的高向特异性 (61%) 和pH 6.5响应.
- 通过使红细胞粘附和持续释放,ODE显著延长了uPA的半衰期至120分钟.
- 在体内血栓形成模型中,与自由的uPA相比,表现出优异的向和血栓溶解.
结论:
- 开发的uPA-CS/HS@RGD-ODE系统提供了一种新的红细胞覆盖策略,用于输送血栓治疗药物.
- 这种方法显著提高了药物循环时间和血栓向效率.
- 这代表了治疗血栓性疾病和预防复发的有希望的进步.
相关概念视频
01:18Drug Delivery: Enteral Route
398
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
398
01:16Drug Delivery: Overview
279
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
279
01:22Drug Delivery: Miscellaneous Routes
329
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329