重新评估Halm在社区获得性肺炎管理中的临床稳定性标准
Simone Bastrup Israelsen1, Markus Fally2, Pernille Brok Nielsen3,4
1Center of Research and Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark simone.elisabeth.bastrup.israelsen.02@regionh.dk.
The European respiratory journal
|August 22, 2024
概括
哈尔姆的社区获得性肺炎 (CAP) 稳定性标准需要在今天的老年,更生病的患者中更长的时间. 早期的稳定性仍然表明并发症较少,特别是那些没有做-不-复苏命令的人.
科学领域:
- 临床医学 临床医学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 1998年建立的Halm临床稳定性标准指导社区获得性肺炎 (CAP) 的治疗和出院.
- 原始标准基于有限的,选择患者队列.
- 需要重新评估当代的,现实世界的农业政策管理.
研究的目的:
- 重新评估Halm临床稳定性标准在当前的CAP患者群体中的适用性.
- 评估临床稳定性和不稳定性复发的时间.
- 分析与临床稳定性里程碑相关的严重并发症和死亡率.
主要方法:
- 在丹麦 (2017-2020年) 对2918名免疫能力较强的CAP患者进行的队列研究.
- 主要结局:根据哈姆标准,达到临床稳定的时间.
- 使用累积发病率和卡普兰-梅尔曲线进行分析,考虑竞争风险.
主要成果:
- 在患有并发症的老年人群 (平均年龄75岁) 中,临床稳定的中位时间为4天.
- 在早期反应 (3天内) 后,五分之一的患者经历了不稳定的复发.
- 在早期响应者中,30天死亡率总体为5.1%,在没有DNR命令的人中较低 (1.7%).
结论:
- 哈姆的标准仍然有效地对CAP疾病过程进行分类.
- 当代,老年患有并发症的患者需要更长时间才能达到稳定.
- 早期临床反应与降低并发症风险相关,特别是在没有做-不-复苏命令的患者中.
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