估计的葡萄糖排放率和亚临床冠状动脉样硬化之间的关联
Myung Jin Kim1, Yun Kyung Cho1, Eun Hee Kim2
1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea; Asan Diabetes Center, Asan Medical Center, Seoul, 05505, Republic of Korea.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|August 22, 2024
概括
低估计的葡萄糖处置率 (eGDR),胰岛素抵抗的标志物,与中年韩国人的冠状动脉样硬化增加有关. 然而,eGDR的效果不如已知的心血管风险模型.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 胰岛素抵抗是糖尿病的一个关键因素.
- 亚临床冠状动脉样硬化是心血管事件的前体.
- 估计的葡萄糖排放率 (eGDR) 是胰岛素耐药性的临床标志物.
研究的目的:
- 研究eGDR与亚临床冠状动脉样硬化之间的关联.
- 为了评估eGDR在无症状,中年韩国人口中的实用性.
主要方法:
- 一组4004名无症状的韩国成年人接受了冠状动脉计算机断层扫描.
- 使用腰围,高血压和糖化血红蛋白计算eGDR.
- 亚临床冠状动脉样硬化被通过狭窄,斑块存在和冠状动脉化 (CAC) 评分和进展来评估.
主要成果:
- 较低的eGDR水平与较高的显著冠状动脉狭窄,斑块和中度至重度的CAC的患病率相关.
- 降低eGDR也与CAC进展有关.
- eGDR显示优于其他胰岛素抵抗生物标志物,但不超过已建立的心血管风险模型.
结论:
- 降低eGDR与该人群中亚临床冠状动脉样硬化增加显著相关.
- 与现有的心血管风险评估工具相比,eGDR的临床实用性有限.
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