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Updated: Jun 15, 2025

A Nanobar-Supported Lipid Bilayer System for the Study of Membrane Curvature Sensing Proteins in vitro
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通过纳米体调节器对Frizzled3的结构洞察力

James Hillier1, Yuguang Zhao2, Loic Carrique1

  • 1Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Nature communications
|August 22, 2024
PubMed
概括

Frizzled3 (FZD3) 的结构揭示了纳米体如何调节其功能. 这些发现揭示了FZD3的真相.

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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