在灵长类动物中,半球间途径对于运动恢复的阶段性作用
Masahiro Mitsuhashi1,2, Reona Yamaguchi3, Toshinari Kawasaki1,4
1Department of Neuroscience, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Nature communications
|August 22, 2024
概括
这项研究揭示,大脑是大脑.
科学领域:
- 神经科学是一个神经科学.
- 运动恢复研究 运动恢复研究
背景情况:
- 非损伤感官运动皮质在受伤后运动恢复中的作用仍在争论中.
- 了解半球间通路对于制定有效的康复策略至关重要.
研究的目的:
- 为了研究前运动皮质内半球间通路的功能.
- 确定其在激活异位传感运动皮质和在椎皮质脊髓损伤后促进运动恢复方面的作用.
主要方法:
- 使用单向化学遗传阻塞在与侧面皮质脊柱管病变.
- 采用电皮质谱来记录运动任务期间的大脑活动.
主要成果:
- 在早期康复阶段,化学遗传阻塞会损害敏捷的手动.
- 半球间通路活动从抑制转移到促进,参与到ipsilesional感觉运动皮质.
- 低频带活动在ipsilesional前运动皮质的阻塞变化取决于恢复阶段.
结论:
- 半球间通路在运动恢复过程中起着阶段性作用.
- 在早期康复阶段准这种途径可能会在皮质脊柱管损伤后增强运动功能.
相关概念视频
Direct Motor Pathways
1.9K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
1.9K
Cerebral Hemispheres
308
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
308
Indirect Motor Pathways
1.4K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.4K
Lateralization
317
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
317
Role of Cerebellum and Prefrontal Cortex in Memory
396
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
396


