特定的多价值分子可以促进CRISPR介导的转录激活

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Updated: Jun 15, 2025

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
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Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018

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Rui Chen1,2,3,4, Xinyao Shi1,3, Xiangrui Yao1,3

  • 1Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.

Nature communications
|August 22, 2024
PubMed
概括

内在无序区域 (IDR) 和模块化域 (MD) 可以增强CRISPR/Cas基因激活. 最佳的合作性,而不是最大的合作性,以及针对促进剂-增强剂相互作用是使用这些多价值分子进行强大的激活的关键.

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