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相关概念视频

RNA Structure01:19

RNA Structure

4.7K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
4.7K
Protein Networks02:26

Protein Networks

3.9K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K
RNA Editing02:23

RNA Editing

8.9K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
8.9K
Nucleic Acid Structure01:25

Nucleic Acid Structure

6.1K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
6.1K
Nucleic Acids02:43

Nucleic Acids

44.0K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
44.0K
Protein-protein Interfaces02:04

Protein-protein Interfaces

12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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相关实验视频

Updated: Jun 15, 2025

Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
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Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

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一个基于本体学的知识图表,用于表示涉及RNA分子的相互作用.

Emanuele Cavalleri1, Alberto Cabri1, Mauricio Soto-Gomez1

  • 1AnacletoLab, Computer Science Department, University of Milan, Milan, 20133, Italy.

Scientific data
|August 22, 2024
PubMed
概括

我们开发了RNA-KG,这是一个全面的知识图,集成了来自60多个数据库的RNA数据. 这个资源集中了关于RNA分子,基因,蛋白质和化学物质的信息,帮助RNA世界研究和药物发现.

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An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA
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A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
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A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

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相关实验视频

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Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

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An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA
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A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
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科学领域:

  • 生物信息学是一种生物信息学.
  • 分子生物学分子生物学
  • 基因组学就是基因组学.

背景情况:

  • 对RNA分子的研究对于理解生物过程和疾病至关重要.
  • 目前的RNA数据在众多公共存储库中分散.
  • 缺乏RNA相关知识的统一和语义上一致的表示.

研究的目的:

  • 为了创建RNA-KG,一个集中的知识图表,为世界.
  • 世界RNA世界RNA世界
  • . . . . . . . . . . . . . . 这就是为什么.
  • 将多样化的RNA数据与基因,蛋白质和化学物质相结合.
  • 为探索和分析RNA相关的生物医学知识提供资源.

主要方法:

  • 来自60多个公共数据库的数据集成.
  • 为本体学描述开发一个元图.
  • 利用语义抽象的知识模型进行本体学对齐.
  • 创建一个SPARQL终点来查询RNA-KG.

主要成果:

  • RNA-KG整合了关于编码和非编码RNA的生物知识.
  • 知识图连接RNA分子与基因,蛋白质和化学物质.
  • 对RNA-KG的拓分析提供了对RNA-KG的洞察力.
  • 世界RNA世界RNA世界
  • . . . . . . . . . . . . . . 这就是为什么.
  • RNA-KG可供下载和直接探索.

结论:

  • RNA-KG为RNA研究提供了一个集中,语义一致的资源.
  • 知识图有助于发现新药和个性化医疗.
  • RNA-KG可以更新新的数据,并适应特定的生物医学问题.