在SARS-CoV-2感染中循环内分类素水平及其在炎症反应中的潜在作用
Maria Velasco1,2,3, Maria Posada-Ayala4, Elia Pérez-Fernández5
1Unidad de Enfermedades Infecciosas, Hospital Universitario Fundación Alcorcón, 28922, Alcorcón, Madrid, Spain. mvelascoa@salud.madrid.org.
Scientific reports
|August 22, 2024
概括
在COVID-19患者中,内分泌大麻素 (eCB) 的血水平发生变化. 在后急性阶段,2-阿拉基多诺伊尔糖醇 (2-AG) 的含量升高,而N-棕乙烯胺 (PEA) 和N-阿拉基多诺伊尔乙烯胺 (AEA) 的含量降低,这表明它们在疾病发病过程中的作用.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 内分泌大麻素 (eCBs) 呈现出动态的血水平,受各种疾病和疾病的影响.
- 众所周知,导致COVID-19的SARS-CoV-2感染会影响多个生理系统.
研究的目的:
- 在急性和后急性感染阶段,在COVID-19患者中量化主要内分泌素 (eCB) 和N-乙烯基乙醇胺 (NAE).
- 研究血eCB水平与关键临床参数 (包括IL-6) 之间的关联.
主要方法:
- 使用液体染色学-并联质谱法 (LC-MS/MS) 来测量eCB水平.
- 分析包括64名参与者:18名健康捐赠者,30名急性COVID-19患者和16名后急性COVID-19患者.
主要成果:
- 与健康个体相比,COVID-19患者的血2-阿拉基多诺伊尔甘油 (2-AG) 水平显著更高.
- 血N-palmitoylethanolamide (PEA) 和N-arachidonoylethanolamide (AEA) 的水平在急性后期样本中降低.
结论:
- 升高的2-AG表明在急性COVID-19期间在炎症反应中发挥了作用.
- 降低PEA和AEA表明eCBs在COVID-19后急性病原发生过程中的潜在参与.
- 感染SARS-CoV-2导致循环内分泌卡纳比诺伊德水平的可测量变化.
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