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与代谢功能障碍相关的肥胖性肝病患者群体中高敏感性托罗邦素和死亡率
Jingjing Hu1, Yuteng Du1,2, Yidan Zhou3
1Department of Emergency Medicine, Hangzhou Third People's Hospital, Hangzhou, China.
Scientific reports
|August 22, 2024
概括
升高的高灵敏性心脏特罗素 (hs-cTn) 在与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者中显著增加死亡风险. hs-cTn水平可以帮助临床医生在这种高患病率人群中分层死亡风险.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 临床生物标志物 临床生物标志物
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 在全球普遍存在,并与不良的心血管疾病 (CVD) 结果相关.
- 有效的风险分层对于MASLD患者至关重要.
- 在MASLD死亡率中,高灵敏性心脏热素 (hs-cTn) 的预后价值仍然不清楚.
研究的目的:
- 调查hs-cTn水平与大规模MASLD队列中所有原因和心血管疾病死亡率之间的关联.
- 确定hs-cTn是否可以作为MASLD患者死亡风险的预测生物标志物.
主要方法:
- 利用了来自NHANES数据库 (1999-2004) 的数据,将hs-cTn水平和并发症与死亡率数据联系起来.
- 使用hs-cTn.的第99个上限参考值 (URL) 确定心肌损伤.
- 包括3460名MASLD患者,平均随访时间为192个月.
主要成果:
- 升高的hs-cTnT (>第99个URL) 与全因死亡率 (aHR=1.93) 和心血管疾病死亡率 (aHR=2.4) 的增加有关.
- 升高的hs-cTnI (>第99个URL) 显示出类似的关联:全因死亡率 (aHR=2.03) 和心血管疾病死亡率 (aHR=2.97).
- 在hs-cTn水平和死亡风险 (P<0.001) 之间观察到显著的非线性剂量反应关系.
结论:
- 高灵敏性心脏托波宁 (hs-cTn) 是MASLD患者死亡率的显著预测因素.
- hs-cTn检测可以帮助临床医生识别MASLD个体,这些个体有较高的全因和心血管疾病死亡风险.
- 建议进行常规的hs-cTn评估,以改善MASLD的死亡风险分层.
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