在接受结核性脑膜炎初始治疗的儿科患者中,尿液的诊断潜力
Simon Isaiah1, Johan A Westerhuis2, Du Toit Loots1
1Human Metabolomics, Faculty of Natural and Agricultural Sciences, North‒West University, Potchefstroom, South Africa.
Scientific reports
|August 22, 2024
概括
尿中代谢物分析显示,在儿童中诊断严重结核性脑膜炎 (TBM) 的可能性很大. 这种非侵入性方法确定了可以帮助诊断TBM的生物标志物,特别是在晚期.
科学领域:
- * 神经感染性疾病.
- * 代谢学 代谢学
- * 儿科传染病 儿童传染病
背景情况:
- *结核性脑膜炎 (TBM) 是结核病的严重并发症,特别是在儿童中.
- *目前的TBM诊断方法,依赖于脑脊液 (CSF),是侵入性的,往往不足.
- * 尿液的代谢概况在诊断神经传染病方面仍然很大程度上未被探索.
研究的目的:
- * 调查小儿科队列中TBM尿路代谢物的诊断潜力.
- * 为了比较TBM患者和健康对照者之间的代谢物概况.
- * 用尿液代谢学来区分轻度和严重的TBM阶段.
主要方法:
- *使用非向的质子磁共振 (1H-NMR) 代谢学.
- *分析了32名儿科TBM患者 (1-3期) 和39名对照组的尿样.
- * 严格的统计标准被应用来确定重要的代谢物;ROC分析被用于诊断潜力的评估.
主要成果:
- * 鉴定出五种重要的尿中代谢物 (1-甲基尼古丁胺,3-基伊索瓦莱里克酸,5-氨基风氨酸,N-乙谷氨胺,甲醇),独立于药物治疗.
- *甲醇的诊断灵敏度较低,而其他四种代谢物显示出良好的诊断潜力.
- *一个多变量代谢模型成功地分类了严重的TBM (2-3阶段),但没有轻微的TBM (1阶段).
结论:
- *尿代谢提供了一个有希望的,非侵入性的途径,用于儿童TBM诊断.
- * 特定的尿路代谢物显示出潜在的生物标志物,用于识别严重的TBM.
- *进一步的研究可以完善基于尿的TBM诊断策略.
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