在怀孕前或怀孕期间诊断的慢性高血压及其对怀孕结果的影响
Qingwen Nie1, Weizhang Liang1, Yuan Xue1
1Department of Obstetrics and Gynecology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China.
Journal of human hypertension
|August 22, 2024
概括
在怀孕早期新诊断的慢性高血压 (CH) 与先前存在的CH相比,增加了早产前和胎盘断裂的风险. 早期监测和干预对于管理这些高风险怀孕至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 心脏病学 心脏病学
- 围产儿医学 围产儿医学
背景情况:
- 怀孕期间慢性高血压 (CH) 存在风险,诊断时间会影响结果.
- 了解怀孕前CH和新诊断的CH在前20周内存在的不同风险对于孕产妇和胎儿的健康至关重要.
- 现实世界的数据对于评估不同患者群体的临床管理和结果至关重要.
研究的目的:
- 为了比较怀孕前诊断的慢性高血压妇女和在头20周内新诊断的妇女之间的不良妊娠结果.
- 为了确定慢性高血压的两个组之间的特定风险因素和管理的差异.
- 为临床实践提供有关怀孕期间早期高血压疾病的监测和干预策略的信息.
主要方法:
- 一项回顾性现实研究分析了从2018年1月到2023年6月的CH单独怀孕.
- 两组的比较:怀孕前的CH (1组) 和在头20周内新诊断的CH (2组).
- 使用后勤回归分析来调整潜在的混因素,并确定不良结果的风险.
主要成果:
- 2组 (新诊断的CH) 与1组相比,妊娠期间体重增加的发生率较高,并且在20周之前接受抗高血压治疗的比例较低.
- 第二组妇女的早产前率 (44.2%对34.9%) 和胎盘断裂 (5.4%对2.0%) 显着更高.
- 调整后的分析显示,在前20周内新诊断的CH与怀孕前的CH相比,早产前的风险增加了1.8倍.
结论:
- 在怀孕前20周内新诊断的慢性高血压与显著增加的孕产妇和胎儿不良后果的风险有关,包括早产子和胎盘断裂.
- 这些发现强调了警监测和及时干预对于在怀孕早期被发现患有新发性CH的孕妇的重要性.
- 需要优化管理策略,以减轻新诊断的早期慢性高血压妇女观察到的高风险.
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