微量营养素摄入量和端粒长度:来自英国生物银行的发现
Marianna Spinou1, Androniki Naska1, Christopher P Nelson2,3
1Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
European journal of nutrition
|August 22, 2024
概括
从食物中摄入的微量营养素与白细胞端粒长度 (LTL) 有很小的关联,而整体补充剂的使用则没有. 特定的维生素如B6和食物中的叶酸与LTL有关,但临床意义仍然不确定.
科学领域:
- 营养科学 营养科学
- 遗传学 是一个遗传学.
- 生物化学 生化学
背景情况:
- 白细胞端粒长度 (LTL) 是细胞衰老的生物标志物.
- 微量营养素的摄入对于细胞健康和功能至关重要.
- 了解饮食和LTL之间的关系可能会为老龄化和慢性疾病预防提供见解.
研究的目的:
- 调查饮食微量营养素摄入量和补充剂使用与LTL之间的关联.
- 为了确定特定的维生素和矿物质是否会影响大量人口队列中的LTL.
主要方法:
- 对422,693名英国生物库参与者 (40-69岁) 的横截面研究.
- 测量LTL是以telomere重复数与单拷贝基因 (z-LTL) 的LOGE转换和z标准化比率来测量.
- 微量营养素摄入量通过自我报告的24小时回忆日记进行评估;补充剂使用通过触摸屏评估. 用于分析的多变量线性回归.
主要成果:
- 整体补充剂摄入量与z-LTL无关.
- 在定期服用维生素B和B9补充剂时观察到较短z-LTL的趋势.
- 饮食摄入的潘托酸,维生素B6,生物素和叶酸与z-LTL有关,其影响根据补充剂的使用而有所不同.
结论:
- 观察到的微量营养素摄入量和LTL之间的负相关性很小,相当于与年龄相关的变化一年或更少.
- 这些关联的临床重要性及其与预防慢性疾病的相关性目前尚不确定.
- 需要进一步的研究来澄清特定微量营养素对LTL和长期健康结果的影响.
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