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Updated: Jun 9, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
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在患有结直肠癌的患者中,美索林表达与抑制性免疫活性升高相关

Midhun Malla1, Sachin Kumar Deshmukh2, Sharon Wu2

  • 1University of Alabama, Birmingham, AL, USA. midhunmalla@uabmc.edu.

Cancer gene therapy
|August 22, 2024
PubMed
概括

介质素 (MSLN) 蛋白在侵袭性结肠直肠癌 (CRC) 中高度表达,特别是在微卫星稳定 (MSS) 亚型中. 高MSLN与免疫抑制相关,并建议MSLN作为MSS CRC的潜在治疗标.

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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...