对因重复举重任务引起的局部肌肉疲劳的生物标志物的分析和研究
Siwu Zhong1, Ning Jia2, Ying Qu2
1Occupational Health Surveillance Center, Guangzhou Twelfth People's Hospital, Guangzhou, 510620, China.
BMC musculoskeletal disorders
|August 22, 2024
概括
像氨 (AMM) 这样的代谢标记物和像神经Y (NPY) 这样的疼痛标记物可以在重复的举重任务中表明局部肌肉疲劳. 这项研究支持早期检测与工作相关的肌肉骨疾病.
科学领域:
- 职业健康 职业健康 职业健康
- 生物标志物研究 生物标志物研究
- 人体工程学就是人体工程学.
背景情况:
- 与工作相关的肌肉骨疾病 (WMSDs) 越来越令人担忧,带来了重大的经济和健康挑战.
- 早期发现和预防局部肌肉损伤对于缓解WMSDs至关重要.
- 识别与疲劳相关的敏感生物标志物可以帮助开发早期预警系统.
研究的目的:
- 在持续的人体工程学负载下分析局部肌肉反应.
- 识别敏感的与疲劳相关的生物标志物,以早期预防肌肉损伤.
- 提供支持探索WMSDs早期预警指标的数据.
主要方法:
- 13名男性大学生进行了模拟的重复性手动举重任务.
- 肌肉疲劳是通过感知劳动 (RPE) 和表面EMG (sEMG) 分析 (JASA) 来评估的.
- 血液样本分析了14种生物标志物,包括代谢,氧化应激,炎症和疼痛标志物.
主要成果:
- 主观和客观的疲劳症状同时发生.
- 氨 (AMM),乳酸 (LAC),肌酸激酶 (CK),乳酸脱酶 (LDH),软骨寡合基质蛋白 (COMP),CTX-II,离子 (Ca2+) 和神经Y (NPY) 的血清水平在疲劳后显著升高 (p <0.05).
- 在疲劳前和疲劳后的标志物水平之间观察到相关性.
结论:
- 代谢标志物 (AMM,LAC,CK,LDH,COMP,CTX-II,Ca2+) 和疼痛标志物 (NPY) 在重复的手动提升中可以反映局部肌肉疲劳.
- 这些生物标志物显示出在人体工程任务中显示肌肉疲劳的潜力.
- 需要进一步的研究来验证这些疲劳生物标志物在不同的人口和工作类型.
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