痴呆症患者的血糖状况与全因死亡率之间的关联:全国性的队列研究
Youn Huh1, Kye-Yeung Park2, Kyungdo Han3
1Department of Family Medicine, Uijeongbu Eulji Medical Center, Eulji University, Gyeonggi- do, South Korea.
Alzheimer's research & therapy
|August 22, 2024
概括
痴呆症患者的葡萄糖失调会增加死亡风险. 维持正常的血糖水平可能会提高痴呆症患者的生存率,特别是糖尿病患者.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 内分泌学 在内分泌学.
背景情况:
- 痴呆症是一个日益严重的全球健康问题,影响认知功能和生活质量.
- 血糖状况是整体健康的关键因素,可能会影响各种慢性疾病的结果.
- 了解血糖控制与痴呆患者死亡率之间的关系对于改善患者护理至关重要.
研究的目的:
- 研究血糖状况 (常态血糖,糖尿病前期,糖尿病) 与被诊断患有痴呆症的个体全因死亡风险之间的关联.
- 分析糖尿病持续时间如何影响痴呆症患者死亡风险.
主要方法:
- 从韩国国家医疗保险服务数据库 (2008-2016) 中,从韩国国家医疗保险服务数据库 (2008-2016) 中确定了146,832名年龄在40岁及以上的痴呆症患者.
- 参与者根据血糖状况进行分类:正常血糖,糖尿病前期或糖尿病 (DM).
- 死亡率状况被追踪到2019年底,分析重点是血糖状况与全因死亡率之间的关联.
主要成果:
- 研究队列 (平均年龄75.1岁) 经历了35.2%的死亡率,平均随访时间为3.7年.
- 糖尿病 (DM) 与没有DM的个人相比,与增加全因死亡风险 (HR 1.34) 有显著关联.
- 长期DM患者 (≥5年) (HR 1.43) 和新诊断的DM患者 (HR 1.35) 的死亡风险最高,短期DM和糖尿病前期患者的风险也较高.
- 这些关联在阿尔茨海默氏症和血管痴呆症亚型中是一致的,对年轻患者的影响更大.
结论:
- 葡萄糖失调,特别是糖尿病,在痴呆症患者中显著增加了全因死亡风险.
- 新诊断的糖尿病和长期存在的糖尿病都会带来严重的死亡风险.
- 建议维持正常的血糖水平,以潜在地提高痴呆症患者的生存结果.
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