在患有关节障碍的人群中识别表型,使用隐性类分析:关节障碍和表型
Elisabeth Heggem Julsvoll1,2, Birgitte Lawaetz Myhrvold1, Knut Waagan3
1Department of Interdisciplinary Health Sciences, Institute of Health and Society, University of Oslo, Oslo, Norway.
Journal of oral rehabilitation
|August 23, 2024
概括
确定了三种独特的关疾病患者表型,有助于个性化治疗. 这些表型基于功能障碍,疼痛和心理因素来表征个体,指导针对TMD的量身定制干预措施.
科学领域:
- 生物医学科学 生物医学科学
- 临床研究 临床研究
- 疼痛管理 疼痛管理
背景情况:
- 部疾病 (TMD) 呈现出显著的异质性,需要个性化治疗方法.
- 生物心理社会模型和对患者表型的关注对于有效的TMD管理至关重要.
研究的目的:
- 在患有TMD的个体中识别不同的表型.
- 分析预后因素,包括个人特征和临床测试反应.
- 检查TMD诊断在已识别的表型中的分布.
主要方法:
- 一项涉及208名因关节问题寻求物理治疗的参与者的横截面研究.
- 隐性类分析被用来定义基于疼痛,功能和心理因素的表型.
- 用临床检查和电子问卷来收集数据.
主要成果:
- 确定了三种表型:表型1 (功能障碍,低心理社会风险),表型2 (非功能习惯,疼痛焦点) 和表型3 (高精神困扰,高慢性风险).
- 现型1与关节内疾病有关; 现型2与肌痛和TMD相关的头痛有关; 现型3包括所有TMD诊断.
- 表型分布为32% (表型1),29% (表型2) 和39% (表型3).
结论:
- 识别的TMD表型为临床实践提供了宝贵的见解.
- 这种表型知识可以为制定有针对性的预防策略提供信息.
- 通过了解这些患者子组,可以加强对TMD的个性化治疗方法.
相关概念视频
Classification of Bones
15.3K
The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
15.3K
Functional Classification of Joints
9.2K
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
9.2K
Structural Classification of Joints
8.9K
Joints, also known as articulations, are classified based on their structural characteristics, i.e., based on whether the articulating surfaces of the adjacent bones are directly connected by fibrous connective tissue or cartilage, or whether the articulating surfaces contact each other within a fluid-filled joint cavity. These differences serve to divide the joints of the body into three structural classifications.
A fibrous joint is where the adjacent bones are united by fibrous connective...
A fibrous joint is where the adjacent bones are united by fibrous connective...
8.9K


