患有MASLD与MASLD的个体的死亡结果和增加的酒精摄入量
Majd B Aboona1, Pojsakorn Danpanichkul2,3, Vincent L Chen4
1University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, USA.
Journal of gastroenterology and hepatology
|August 23, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的饮酒量增加 (MetALD) 与单独使用MASLD相比,癌症死亡风险更高. 准确的酒精评估对于管理MASLD和MetALD患者至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- 与饮酒相关的代谢功能障碍脂肪性肝病 (MetALD) 是一个新描述的实体.
- 对于MetALD和MASLD的比较自然历史,人们仍然在很大程度上不知道.
研究的目的:
- 为了比较患有MASLD与MetALD的患者的纵向健康结果.
- 调查MASLD和MetALD队列之间的整体,心血管,癌症相关和其他死亡原因的差异.
主要方法:
- 利用了来自国家健康和营养检查调查 (2011-2018) 的数据.
- 使用美国脂肪肝指数 (>30) 和心脏代谢标准来定义MASLD.
- 定义MetALD为MASLD,并为男性和女性设定特定的每日酒精摄入量值.
主要成果:
- 包括2838名MASLD和2557名MetALD患者,随访时间中位数为56个月.
- 在MetALD患者中,癌症相关死亡风险显著增加 (HR 1.32;P < 0.01).
- 两组之间在总体,心血管或其他死亡原因方面没有发现显著差异.
结论:
- 与MASLD患者相比,MetALD患者的癌症相关死亡风险更高.
- 强调需要对MASLD患者进行警的癌症监测.
- 强调精确对酒精消费进行分类的重要性,以改善患者的治疗结果.
更多相关视频
相关概念视频
Stress Prevention and Stress Management Techniques IV
28
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
28
Pulmonary Tuberculosis I
227
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
227
CNS Depressants: Alcohol and Nicotine
183
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
183
Stress and Mental Health
89
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
89
Mismatch Repair
4.8K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
4.8K


