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[怀孕对多发性硬化症的影响]

I V Zakroyshchikova¹, T O Simaniv¹, D O Zemlyanaya²

¹Research Center of Neurology, Moscow, Russia.

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

|August 23, 2024

概括

计划怀孕多发性硬化症 (MS) 是复杂的,因为担心疾病修饰治疗 (DMT). 本综述涵盖了怀孕期间的免疫变化以及DMT对生育和胎儿发育的风险.

科学领域:

神经学神经学
免疫学免疫学免疫学
生殖医学生殖医学

背景情况:

多发性硬化症 (MS) 影响生育年龄的女性,引发了对计划怀孕和疾病修饰治疗 (DMT) 的担忧.
很大一部分患有多发性硬化症的妇女 (14%) 拒绝计划怀孕,因为担心怀孕过程,结果和DMT的影响.
担忧包括DMT的潜在原性,对生育能力的影响,以及疾病传播给后代.

研究的目的:

在MS患者怀孕期间审查免疫变化.
提供有关计划怀孕的所有DMT组的数据.
概述DMT对生育能力和胎儿发育 (子性) 的潜在风险.

主要方法:

文献综述和关于多发性硬化症,怀孕和DMT的数据综合.
在MS患者怀孕期间免疫反应的分析.
关于各种DMT与生殖健康有关的安全数据的汇编.

主要成果:

在MS患者中,怀孕涉及自然保护性免疫反应.
关于DMT,生育力和产性的数据被介绍为明智的决策.
了解这些因素可以帮助解决患者的担忧,并指导治疗策略.

结论:

有关MS妇女怀孕计划的知情决策需要关于DMT的全面数据.
解决关于DMT,生育和胎儿发育的担忧对于患者护理至关重要.
进一步的研究可能会阐明长期影响并优化管理策略.

关键词:

改变疾病的治疗方法.怀孕中的免疫病理机制多发性硬化症多发性硬化症怀孕怀孕怀孕怀孕怀孕

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