在制药,临床和法医矩阵中测定西拉的分析方法 - - 综述
Sachil Kumar1, Hemi Gayakwad2, Tulsidas R Baggi3,4
1Amity Institute of Forensic Sciences, Amity University, Noida, Uttar Pradesh, India.
Medicine, science, and the law
|August 23, 2024
概括
克西拉是一种未经批准用于人类的兽医药,越来越多地与过量服用死亡有关. 本文重点介绍了法医分析方法,用于在各种样本中检测氨酸,并主张使用经过验证的技术.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 一种兽医镇静剂西拉,在过量死亡事件中越来越多地被检测到.
- 它的非阿片类药物性质和仅限兽医许可证使人类使用的检测变得复杂.
- 全球越来越多的担忧需要强大的法医分析方法.
研究的目的:
- 审查和分析西拉使用的法医方面.
- 强调克西拉的化学,临床和毒理学分析.
- 倡导在法医调查中使用验证的分析方法来确定西拉.
主要方法:
- 在2023年4月之前,对主要科学数据库 (谷歌学者,Scopus,Science Direct,PubMed) 进行全面的文献搜索.
- 评估了79篇文章,其中40篇符合滥用西拉的入选标准和分析方法.
- 专注于样品制备 (SPE,LLE) 和分析技术 (GC-MS,LC-MS/MS,HPLC-DAD). 通过测试和分析方法,我们可以更好地测试样品.
主要成果:
- 最常见的克西拉暴露是偶然和故意的滥用/滥用.
- 临床表现包括低血压,心肌梗塞,昏昏欲睡和昏昏欲睡.
- 液体染色学-双重质谱法 (LC-MS/MS) 目前是首选的黄金标准方法.
结论:
- 经过验证的分析方法对于在法医毒理学中准确检测西拉至关重要.
- LC-MS/MS是黄金标准,但替代方法显示了未来的潜力.
- 实验室需要进一步开发查和确认方法.
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