在并发性创伤后应激障碍和甲基胺使用障碍中使用布罗
Jamie Kneebusch1, Sanaz Farhadian2
1University of California, San Diego - Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA, USA.
Journal of pharmacy practice
|August 23, 2024
概括
布普罗可能有助于治疗同时发生的创伤后应激障碍 (PTSD) 和甲基胺使用障碍 (MUD). 这项研究表明,与其他治疗方法相比,布罗的使用导致PTSD症状减少,复发较少.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 成 药物 药物 药物 药物
背景情况:
- 并发性创伤后应激障碍 (PTSD) 和物质使用障碍 (SUD) 是常见的.
- 血清增强剂是标准的PTSD治疗方法,但布洛普的作用不太确立.
- 新兴研究表明,布洛普可能对甲基胺使用障碍 (MUD) 有效.
研究的目的:
- 评估布罗在患有并发性PTSD和MUD的患者中的疗效.
- 为了比较包括布洛普在内的疗法与用于PTSD症状和MUD复发的传统药物治疗.
主要方法:
- 一个由四名患有并发性PTSD和MUD的Bupropion治疗患者组成的病例系列.
- 与41名仅接受血清激素药物治疗的患者的对照组进行了比较.
- 分析PTSD检查清单-平民得分,复发率,复发时间和医院利用率.
主要成果:
- 与非布普罗组相比,布普罗组的PTSD检查清单得分明显较低 (77到29分),而非布普罗组的得分则为51±15到53±10分.
- 布鲁与较低的复发率 (25.0%与48.8%) 和减少医院利用率 (0%与29.3%) 相关.
- 复发的平均时间在布普罗组较短 (107天vs210±191天).
结论:
- 布普罗皮昂在患有并发性MUD的患者中减轻PTSD症状严重性的潜在好处.
- 研究结果表明,布洛可能会降低甲基胺复发频率和住院治疗.
- 这一案例系列支持对患有PTSD和同时发生的MUD的个体考虑更早地启动布洛.
相关概念视频
Antidepressant Drugs: MAOIs and Other Agents
205
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
205
Drug Abuse and Addiction: Pharmacological Phenomena
451
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
451
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
337
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
337
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
169
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
169
CNS Depressants: Alcohol and Nicotine
183
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
183
Binge Eating Disorders
58
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
58


