肠道微生物群和甲状腺结节之间的因果关系:双向的双样本孟德尔随机化研究

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Shaoshuai Yan^1,2, Jiawei He³, Xudong Yu^1,2

¹Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Frontiers in endocrinology

|August 23, 2024

概括

肠道微生物群的组成与甲状腺结节 (TNs) 有因果关系. 某些细菌可能会对TNs进行保护,而其他细菌则会增加风险,突出显示甲状腺-肠轴用于预防和管理.

科学领域:

微生物组研究的研究.
内分泌学在内分泌学.
遗传学是一个遗传学.

背景情况:

新出现的证据将肠道微生物群 (GM) 的变化与甲状腺结节 (TNs) 联系起来.
转基因和TN之间的因果关系尚不清楚.
了解这种联系对于甲状腺健康管理至关重要.

研究的目的:

使用孟德尔随机化 (MR) 调查肠道微生物群组成和甲状腺结节的发展之间的因果关系.
为了识别可能影响TN风险或提供保护的特定肠道细菌.

主要方法:

利用来自大型联盟 (MiBioGen和FinnGen) 的总结统计数据进行MR分析.
采用了各种MR技术,包括逆方差加权,MR-Egger,加权中位数和MR-PRESSO.
通过严格的统计调整,进行了单变量,多变量和反向MR分析.

主要成果:

确定了与TNs潜在的因果关联的特定肠道细菌.
鲁米诺可可科科 (Ruminococcaceae_NK4A214_group),塞内加利马西利亚 (Senegalimassilia) 和拉克诺斯皮拉科 (Lachnospiraceae) 植物表现出具有保护性的作用.
脱硫纤维菌,Prevotella_7,Faecalibacterium,Desulfovibrionaceae和Deltaproteobacteria与TN风险的增加有关.
反向MR分析没有揭示相反方向的显著因果关系.
经过调整后,Desulfovibrionales (顺序),Desulfovibrionaceae (家族) 和Deltaproteobacteria (类) 仍然具有重要意义.

结论:

这项研究提供了强有力的证据,证明肠道微生物群组成和甲状腺结节的发展之间存在显著的因果关系.
这些发现凸显了甲状腺-肠轴在理解TNS方面的重要性.
转基因分析可能为转基因病毒的预防和管理策略提供新的途径.

关键词:

门德尔的随机化有因果关系的因果关系.我们的肠道微生物群.甲状腺结节甲状腺结节甲状腺 - 肠轴

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