对于甲状腺激素的敏感性和胰岛素耐药性之间的关联在患有肥胖症的成人中
Ying Wei1, Xingang Li1, Ruixiang Cui1
1Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Frontiers in endocrinology
|August 23, 2024
概括
降低甲状腺激素 (TH) 敏感性与肥胖成年人脂肪组织胰岛素耐药性增加有关. 这突显了TH的灵敏度.
科学领域:
- 内分泌学 在内分泌学.
- 代谢综合征研究 代谢综合征研究
- 甲状腺激素生理学 甲状腺激素生理学
背景情况:
- 甲状腺激素 (TH) 敏感性受损是与代谢综合征相关的已知因素.
- 肥胖是代谢功能障碍的重要危险因素,包括胰岛素抵抗.
研究的目的:
- 为了研究中枢甲状腺激素敏感度指数和胰岛素抵抗 (IR) 在肥胖的非甲状腺成年人之间的关系.
- 确定中央TH敏感性的特定测量是否与不同类型的胰岛素抵抗相关.
主要方法:
- 一项涉及293名患有肥胖症的甲状腺外科患者的横截面研究.
- 使用基于量子的甲状腺反指数 (TFQI),甲状腺刺激激素指数 (TSHI) 和甲状腺增生性T4抵抗指数 (TT4RI) 评估了中心TH敏感性.
- 用HOMA-IR,肝脏-IR,马苏达指数和脂肪组织胰岛素抵抗指数 (Adipo-IR) 来评估胰岛素耐药性. 用多个线性回归来进行分析.
主要成果:
- 在TH敏感度指数的三位体中观察到HOMA-IR和Adipo-IR的显著逐步增加 (P<0.05).
- 在对共变量进行调整后,只有Adipo-IR仍然与TH敏感性指数有显著的关联.
- 增加的TFQI,TSHI和TT4RI与增加的Adipo-IR相关 (分别P=0.053,P=0.04,P=0.03).
结论:
- 降低中央甲状腺激素敏感性与肥胖的非甲状腺成年人脂肪组织胰岛素抵抗性增加有关.
- 这些发现强调了甲状腺激素敏感性在代谢疾病发展中的关键作用.
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