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在创伤性脑损伤后,biperiden作为抗原的初步临床证据 - 一个随机临床试验

Maira Licia Foresti^1,2, Eliana Garzon^3,4, Mariana Teichner de Moraes³

¹Neurology Neuroscience Postgraduation Program, Physiology Department, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Frontiers in neurology

|August 23, 2024

概括

在创伤性脑损伤 (TBI) 的成年人中,Biperiden没有预防创伤后 (PTE). 该研究没有发现PTE预防的证据,并指出双组的发作频率增加.

科学领域:

神经学神经学
临床试验临床试验
药理学药理学是指药理学的学科.

背景情况:

创伤后 (PTE) 缺乏有效的预防干预措施.
抗胆固醇剂在PTE预防方面显示出临床前的前景.

研究的目的:

评估biperiden在急性创伤性脑损伤 (TBI) 后预防PTE的疗效.

主要方法:

一个随机,双盲,安慰剂对照试验,涉及123名急性TBI的成年人.
参与者接受了双或安慰剂10天.
主要结局:PTE发生率;次要结局:发作频率,不良事件,24个月死亡率.

主要成果:

比皮雷丁对PTE发病率 (p=0.170) 或死亡率 (p=0.248) 没有显著影响.
双组经历了较高的晚期创伤后发作的频率 (p<0.001).
由于COVID-19大流行,试验被提前停止.

结论:

没有足够的证据支持TBI后对PTE预防的biperiden.
需要进行更大规模的研究来澄清biperiden的作用和安全性.

关键词:

急性创伤性脑损伤是什么这是一种抗胆性抗胆药物.这是一个双重居住区.是一种.后创伤性 - - 后创伤性发作发作发作

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Traumatic Brain Injury l: Introduction

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DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...