在严重烧伤后,对P蛋白的新出现的自身抗体
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Tabael L Turan1, Holger J Klein2,3, Theresia Reding Graf4
1Institute for Experimental Endocrinology, Max Rubner Center for Cardiovascular Metabolic Renal Research, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Frontiers in immunology
|August 23, 2024
概括
对蛋白P (SELENOP-aAb) 的自身抗体在8.4%的严重烧伤患者中出现,与烧伤严重程度有关,并可能损害运输. 这些发现凸显了严重受伤后的新型自身免疫反应.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 蛋白P (SELENOP) 是一种来自肝脏的载体,在危急疾病中降低,并且是一种自身抗原.
- 炎症,Se缺乏和药物会影响单蛋白生物合成和单半氨酸插入.
- 严重的烧伤会导致炎症和耗尽,可能损害蛋白合成.
研究的目的:
- 调查严重烧伤损害损害蛋白生物合成的假设,导致对SELENOP (SELENOP-aAb) 的自身抗体.
- 分析烧伤患者的纵向血清样本,以检测SELENOP-aAb的发病和患病率.
主要方法:
- 在六个月内对来自严重烧伤患者的血清样本进行纵向分析.
- 检测新发生的SELENOP-aAb.Ab 的检测.
- 对SELENOP-aAb患病率与损伤严重程度,血清,SELENOP度和谷氨过氧化酶3 (GPx3) 活性的相关性分析.
主要成果:
- 新发现的SELENOP-aAb在8.4%的烧伤患者中被发现,至少在受伤后两周出现.
- 塞勒诺普aAb的患病率与烧伤严重程度相关 (aAb阳性患者的患病率更高).
- 在SELENOP-aAb和全血清Se或SELENOP水平之间没有关联;在aAb阳性患者中观察到GPx3正常化受损.
结论:
- 在严重受伤后的一小部分患者中出现了SELENOP-aAb,可能会对抗运输.
- 烧伤伤害是新发SELENOP-aAb的直接触发因素,对重症患者来说很重要.
- 需要进一步的研究来了解SELENOP-aAb在严重烧伤患者的临床影响.
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