色剂如何影响前列腺癌风险,病理和治疗结果
Awais Paracha1, Zohair Siddiqui1, Ali Abid2
1Saint Louis University School of Medicine, Saint Louis, MO, USA.
Current urology
|August 23, 2024
概括
与未接触过的个人相比,暴露于剂 (AO) 的退伍军人在前列腺癌 (PC) 存活率上没有显著差异. 目前的证据不支持对暴露于AO的退伍军人进行PC诊断或管理的独特方法.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 退伍军人健康 退伍军人的健康
背景情况:
- 数以百万计的退伍军人在越南战争期间服役,美国军方散布了色剂 (AO).
- AO是众所周知的几种癌症的风险因素,但其与前列腺癌 (PC) 的关联不太清楚.
- PC是全球领先的癌症诊断,也是全球男性癌症相关死亡的原因.
研究的目的:
- 综合现有关于色剂暴露对前列腺癌发病率和病程影响的文献.
- 调查AO暴露退伍军人的前列腺癌是否与一般人群病理不同.
- 评估有关在AO暴露的退伍军人中诊断和治疗前列腺癌的现有证据.
主要方法:
- 通过使用与剂和前列腺癌相关的术语进行了全面的PubMed文献搜索.
- 包括从1950年起发表的研究,重点是人类参与者和英语.
- 从最初的108项确定进行系统审查的相关研究中选择了13项相关研究.
主要成果:
- 关于AO暴露与PC发病率,诊断时的年龄和严重程度的关系的发现是混合和相互矛盾的.
- 文献表明,在AO暴露和未暴露的退伍军人之间,PC的生存率没有显著差异.
- 异质的结果表明,AO暴露不需要显著不同的PC管理方法.
结论:
- 目前的证据不支持在暴露于色剂的退伍军人中针对前列腺癌的独特诊断或管理策略.
- 临床医生应考虑个人病人的因素来决定PC查和治疗决定在这个人群.
- 建议对每个病例进行个别评估,平衡临床怀疑与治疗和治疗的潜在危害.
关键词:
2,3,7,8-Tetrachlorodibenzo-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin 2,3,7,8-Tetrachlorodibenzo-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-dioxin-p-p-dioxin-p-p-dioxin-p-p-dioxin-p-p-p-dioxin-p-p色剂是什么?色剂是什么?前列腺癌是什么意思 前列腺癌是什么意思退伍军人退伍军人退伍军人更多相关视频
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