相关实验视频
Updated: Jun 15, 2025

08:52
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
10.6K
对于疫苗可以预防的传染病,当地疫苗授权可能会产生反直觉的影响
Maddalena Donà1, Pieter Trapman1
1Faculty of Science and Engineering, University of Groningen, Netherlands.
Mathematical biosciences and engineering : MBE
|August 23, 2024
概括
学校的本地疫苗授权可能会增加医疗豁免儿童的疾病爆发和感染风险,即使人口疫苗覆盖率很高. 这种情况发生在未接种疫苗的儿童被转移到没有授权的学校时.
科学领域:
- 流行病学 流行病学
- 数学建模的数学建模
- 公共卫生 公共卫生
背景情况:
- 疫苗可预防的传染病,如麻疹和百日咳,主要影响未接种疫苗的儿童.
- 正在考虑为学校提供本地疫苗授权,以控制疾病传播.
研究的目的:
- 模拟基于学校的疫苗授权对传染病爆发的影响.
- 根据这些任务,评估医疗豁免儿童的感染风险.
主要方法:
- 使用一个随机SIR (易受感染,感染,恢复) 模型,并进行双层混合 (家庭和人口).
- 模拟场景,学校可以实施对学生的疫苗授权,不包括医疗豁免.
主要成果:
- 当地的疫苗授权,即使在高人口疫苗覆盖率附近群体免疫力,可以矛盾地增加疫情的概率.
- 由于未接种疫苗的人口转移到没有授权的学校,医疗豁免儿童的感染风险可能会增加.
结论:
- 学校级的疫苗授权要求仔细考虑人口动态.
- 局部公共卫生干预可能会产生意想不到的后果,例如增加弱势群体的爆发风险.
相关概念视频
Vaccinations
44.2K
Overview
44.2K
Healthcare Associated Infections II: Preventive Measures
2.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.6K
Cross-reactivity
31.0K
Overview
31.0K
Local Anesthetics: Adverse Effects
399
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
399
Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K
Active versus Passive Immunity
598
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
598

