将生物医学本体学与生物转换器合并
Safaa Menad1, Saïd Abdeddaïm1, Lina F Soualmia1
1Univ Rouen Normandie, Normandie Univ, LITIS UR 4108 F-76000 Rouen, France.
Studies in health technology and informatics
|August 23, 2024
概括
本研究介绍了健康本体融合 (SiMHOMer) 的语模型,以整合生物医学知识. 该框架使用人工智能来发现新的关系,改善医疗数据组织和检索.
科学领域:
- 生物医学信息学 生物医学信息学
- 医疗保健中的人工智能
背景情况:
- 实体学对于构建生物医学知识至关重要.
- 现有的本体学缺乏全面的概念和关系.
- 在医疗保健中,高效的数据结构,编码和检索是至关重要的.
研究的目的:
- 建议SIMHOMer (健康本体融合的姆模型) 用于医疗本体的语义融合.
- 最初将重点放在整合与疾病,症状,药物和不良事件有关的本体学上.
- 为增强的应用程序开发一种新的合并本体.
主要方法:
- 利用在生物医学数据上训练的姆神经模型 (BioSTransformers).
- 雇佣了生物转换器来识别新的概念关系并创建新的语义链接.
- 通过UMLS元词库和语义网络验证了方法并确定了关系.
主要成果:
- 证明了框架能够识别生物医学概念之间的新相关关系的能力.
- 成功地为本体学合并产生了新的语义关系.
- 使用UMLS元词库和语义网络进行初始验证显示出有希望的结果.
结论:
- SiMHOMer框架为语义上合并医疗保健本体学提供了一个有希望的方法.
- 鉴定到的新关系有助于建立一个更全面,更综合的生物医学知识库.
- 这项研究为改善医疗数据管理和分析的应用铺平了道路.
相关概念视频
Synthetic Biology
4.7K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
4.7K
Types of Genetic Transfer Between Organisms
5.3K
5.3K
Genome Annotation and Assembly
18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K
Transgenic Organisms
31.0K
Overview
31.0K
Forced Transdifferentiation
1.9K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
Artificial...
1.9K
Improving Translational Accuracy
2.5K
2.5K


