阿尔茨海默病亚洲队列 (ACAD) 试点研究:越南裔美国人
Guerry M Peavy1,2, Namkhuê Võ1, Carolyn Revta1
1Department of Neurosciences, Alzheimer's Disease Cooperative Study.
Alzheimer disease and associated disorders
|August 23, 2024
概括
这项试点研究表明,招募老年越南裔美国人参与阿尔茨海默病 (AD) 研究的可行性. 文化适应的方法成功评估了认知功能,并确定了该人群中常见的风险因素.
科学领域:
- 老年学和认知神经科学
- 神经退行性疾病的流行病学
背景情况:
- 阿尔茨海默病 (AD) 研究在历史上代表不同老龄化人口不足.
- 年长的越南裔美国人面临着参与健康研究的独特障碍.
研究的目的:
- 评估招募老年越南裔美国人参与阿尔茨海默病 (AD) 研究的可行性.
- 在这个人口群体中探索AD的遗传和非遗传风险因素.
主要方法:
- 在圣地亚哥社区招募26名越南裔美国人.
- 利用双语/双文化人员对认知,神经精神和生活方式因素进行远程评估.
- 收集的唾液用于DNA分析和诊断的认知状态 (正常控制,轻度认知障碍,痴呆症).
主要成果:
- 25名参与者完成了这项研究 (平均年龄为73.8岁),其中80%的人更喜欢越南语交流.
- 诊断包括18个正常对照组,3个轻度认知障碍,4个痴呆症.
- 主观认知投诉与抑郁症状和客观认知缺陷相关;88%的人报告至少有一个血管风险因素.
结论:
- 基于社区的研究是可行的,在老越南裔美国人使用文化适应的方法.
- 开发适当的语言评估工具对于未来的研究至关重要.
- 探索性发现突出了这一群体中阿尔茨海默病的潜在非遗传风险因素.
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