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Updated: Jun 15, 2025

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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开发和比较模型综合证据方法,用于与药物动力学终点的生物等价性研究

Xiaomei Chen1, Henrik B Nyberg1, Mark Donnelly2

  • 1Department of Pharmacy, Uppsala University, Uppsala, Sweden.

CPT: pharmacometrics & systems pharmacology
|August 23, 2024
PubMed
概括

使用非线性混合效应模型进行模型综合证据 (MIE) 分析,改善了稀疏的药理动力学数据的生物等价性评估. 采样的重要性重新采样 (SIR) 控制I型错误,提供比非分区分析更高的功率.

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