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手术后的Ga-DOTATATE正子发射断层扫描在偶发的尾神经内分泌瘤中产量较低

Emilie Pauvert^1,2, George Larcos^1,3

¹Sydney Medical School, University of Sydney, Sydney, Australia.

ANZ journal of surgery

|August 23, 2024

概括

使用68Ga-DOTATATE的术后正子发射断层扫描 (PET) 在偶发的尾神经内分泌瘤 (NETs) 中很少呈阳性. 预留PET成像用于患有大瘤 (>20毫米) 或杯状细胞特征的患者,以优化其使用.

科学领域:

在瘤学瘤学.
核医学就是核医学.
胃肠病学胃肠病学

背景情况:

尾神经内分泌瘤 (NETs) 通常是尾切除过程中的偶然发现.
术后成像,特别是68Ga-DOTATATE PET对于这些偶然的NET的有用性尚未得到充分证实.
目前关于后续成像的指导方针缺乏.

研究的目的:

描述68Ga-DOTATATE PET在偶然发现的尾NET患者中的发现.
评估手术后68Ga-DOTATATE PET在治疗这些患者中的作用.
根据瘤特征和PET发现,为未来的成像策略提供信息.

主要方法:

从2009年至2018年间诊断出偶发的尾NET的30名患者的47个68Ga-DOTATATEPET扫描的回顾性审查.
分析截图发现,组织病理学数据 (瘤大小,等级,杯状细胞特征) 和临床结果.
PET结果与患者随访数据的相关性.

主要成果:

大多数患者 (15/30) 的尾NET小 (<10毫米),基67低 (<2%).
只有一个患有大瘤 (40毫米) 和低等级的患者显示出阳性PET检测结果;所有其他29名患者的扫描结果都是负面的.
在27名患者中没有观察到任何复发的神经内分泌疾病,平均随访时间为57个月.

结论:

手术后的68Ga-DOTATATE PET在偶尔检测到的尾NET中主要是负的.
对于具有较大的瘤 (>20毫米) 或具有杯状细胞特征的患者,应选择性考虑PET成像.
这种方法可以帮助完善使用先进的成像来管理偶然的尾 NET.

关键词:

在PET成像中使用PET成像.附录是附录中的附录.神经内分泌瘤的神经内分泌瘤

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