正常衰老和阿尔茨海默病病理学的加速脑容量下降的融合
Bárbara Avelar-Pereira1,2, Curran Michael Phillips1, S M Hadi Hosseini1
1Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA, USA.
Journal of Alzheimer's disease : JAD
|August 23, 2024
概括
健康衰老中的加速脑缩与阿尔茨海默病 (AD) 区域重叠. 识别这些区域,比如前骨,可能有助于检测正常老龄化个体的早期AD症状.
科学领域:
- 神经成像是一种神经成像.
- 老年学是一门学科.
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 年龄是阿尔茨海默病 (AD) 的主要危险因素.
- 在AD受影响的大脑区域和正常衰老下降的大脑区域之间存在相似之处.
- 阿尔茨海默氏症和正常衰老之间的区别可能代表一个频谱.
研究的目的:
- 在健康的老年人中确定加速缩的大脑区域.
- 确定这些地区与受AD影响的地区之间的重叠.
- 调查加速缩和粉样β沉积之间的关联.
主要方法:
- 利用了来自137名健康老年人的纵向磁共振成像 (MRI) 和正子发射断层扫描 (PET) 数据 (阿尔茨海默病神经成像计划).
- 采用线性混合效应模型来分析经过时间的区域大脑体积变化.
- 专注于确定缩率超过平均水平0.5标准偏差的地区.
主要成果:
- 23个大脑区域在两年内出现了加速缩 (0.5 SD高于平均水平).
- 52%的这些地区重叠在一个匹配的AD队列中表现出类似下降的地区.
- 在左前,右上额头,横 temporal 和上 temporal 中注意到加速下降;前缩小与粉样蛋白负荷相关.
结论:
- 在正常衰老过程中,特定大脑区域的加速缩可能表明早期的AD病理.
- 这些发现表明正常衰老和阿尔茨海默病之间存在潜在的连续性.
- 识别这些模式可能有助于在风险人群中早期发现AD.
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