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中国老年人高频听力损失,海马体积和运动认知风险综合征:一项基于人口的研究

Qinghua Zhang^1,2,3, Shicheng Zhao², Jianli Feng⁴

¹Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Journal of Alzheimer's disease : JAD

|August 23, 2024

概括

高频听力损失增加了老年人运动认知风险综合征 (MCR) 的风险. 海马可以调解这种关联,突出显示干预的潜在途径.

科学领域:

老年学是一门学科.
神经科学是一个神经科学.
听力学听力学是指听力学.

背景情况:

老年人听力损失,海马体积和运动认知风险综合征 (MCR) 之间的关系仍未得到充分研究.
了解这些关联对于开发针对老年人群认知和运动衰退的有针对性的干预措施至关重要.

研究的目的:

检查听力损失和MCR之间的联系,以及听力损失和海马体积之间的联系.
研究听力损失和海马体积对MCR的相互作用效应.

主要方法:

一项以人口为基础,对2540名无痴呆症的中国成年人 (≥60岁) 进行的横截面研究.
听力功能通过纯音调听力测量评估;海马体体积用MRI测量在一个子样本 (n=661).
后勤回归模型用于数据分析.

主要成果:

高频听力损失与增加的MCR和缓慢的步伐有显著的关联.
在高频听力和海马体体积之间观察到一个反转的U形关系.
较大的海马体积与减少的MCR和主观认知衰退 (SCD) 相相关.
显著的相互作用表明,听力损失对MCR和缓慢步行的影响仅在没有听力损失的个体中存在.

结论:

高频听力损失与老年人MCR的可能性更高有关.
海马似乎在高频听力损失和MCR之间的关联中发挥着作用.

关键词:

衰老的衰老衰老的衰老阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.听力损失听力损失是什么在海马体内,海马体容量运动性认知风险综合征

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