在儿童癌症治疗中的合作创新
Iris Valtingojer1, Sasha Lièvre2, Philippe Bordes3
1Department of Oncology, R&D, Sanofi, Vitry-sur-Seine, France. Iris.Valtingojer@sanofi.com.
Handbook of experimental pharmacology
|August 23, 2024
概括
儿童癌症的生存率有所改善,但治疗创新落后于成人癌症护理. 合作对于推进儿科癌症治疗和解决未满足需求至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症治疗方法 癌症治疗方法
- 翻译研究是翻译研究.
背景情况:
- 儿童癌症的生存率在60年内超过80%,但它仍然是儿童疾病相关死亡的主要原因.
- 大多数儿童癌症幸存者经历了显著的短期和长期治疗毒性.
- 在过去的15年里,儿童癌症治疗的创新并没有跟上成人癌症治疗的进步.
研究的目的:
- 突出改善儿科癌症治疗创新的关键需求.
- 强调成人和儿科瘤学之间日益扩大的治疗发展差距.
- 倡导加强合作努力,以加快治疗儿童癌症的进展.
主要方法:
- 对儿童癌症护理的历史结果和当前挑战的审查.
- 分析成人和儿童癌症治疗之间的科学创新差异.
- 确定需要在瘤学社区内共同关注的关键领域.
主要成果:
- 在儿童癌症存活率方面取得了显著进展.
- 与成人癌症护理相比,儿童癌症治疗创新存在显著的滞后.
- 治疗毒性仍然是儿童癌症患者的主要担忧.
结论:
- 弥合成人-儿科治疗发展差距需要紧急,协作行动.
- 优先考虑在癌症表征,目标验证和药物发现方面的共同努力是必不可少的.
- 加强合作对于改善与癌症作斗争的儿童的结果至关重要.
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Tumor Immunotherapy
493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493
Cancer Vaccines
347
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
347
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Bone Marrow Sampling and Transplants
316
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
316


