基于食物的干预作为炎症性肠病的治疗方法:饮食试验设计和结果报告中的重要步骤
Alice S Day1,2,3, Tessa M Ballard1,4, Chu K Yao5
1Department of Gastroenterology and Hepatology, Inflammatory Bowel Disease Services, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville South 5011, South Australia, Australia.
Inflammatory bowel diseases
|August 23, 2024
概括
为炎症性肠病 (IBD) 设计有效的饮食治疗试验需要标准化的方法. 本综述强调了当前IBD饮食干预研究中的关键差距,并为未来的研究提出了建议.
科学领域:
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
- 基于证据的医学基于证据的医学.
背景情况:
- 饮食疗法是炎症性肠病 (IBD) 的一个关键研究领域.
- 目前设计IBD特异性饮食试验的指导不够.
- 在现有的IBD饮食干预研究中存在显著的异质性.
研究的目的:
- 批判性地评估未来IBD基于食品的干预试验的关键元素.
- 发现IBD饮食研究的设计和方法上的差距.
- 为改善未来IBD饮食试验质量提供建议.
主要方法:
- 从电子数据库中对干预性IBD饮食研究进行系统审查.
- 包括使用基于食物的饮食策略的前性初级研究.
- 试验设计,方法,终点和遵守报告的分析.
主要成果:
- 确定了40项评估29种基于食物的策略的研究,显示出相当多的异质性.
- 许多试验缺乏客观的炎症终点,并且没有对药物稳定性进行控制.
- 坚持饮食治疗的评价很差,并且在不到60%的试验中报告了.
结论:
- 不一致的试验设计和方法限制了IBD饮食治疗研究的解释性和有效性.
- 未来的IBD饮食试验必须采用严格的质量标准,类似于其他IBD疗法.
- 提供了建议,以指导设计高质量的IBD饮食干预研究.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
329
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
329
01:29Inflammatory Bowel Disease IV: Pharmacological Management
123
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
123
01:30Irritable Bowel Syndrome III: Medical and Nursing Management
187
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
187
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
145
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
145
01:21Inflammatory Bowel Disease V: Surgical Management
133
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
133
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
98
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
98