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创伤后的肺炎会引起一种独特的血液微生物特征
Jennifer A Munley1, Lauren S Kelly1, Gwoncheol Park2
1Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.
Shock (Augusta, Ga.)
|August 23, 2024
概括
肺炎的严重创伤增加了肠道的透性,并导致细菌病,改变了血液微生物群. 这项研究揭示了此类伤害后血液微生物组合的显著性别差异.
科学领域:
- 关键护理医学 关键护理医学
- 微生物学 微生物学
- 创伤外科 手术 创伤外科
背景情况:
- 之前的研究表明,创伤后存在病原生物组,但创伤后败血症对肠道透性和细菌转移的影响尚不清楚.
- 多创伤与创伤后肺炎相结合可能会损害肠道屏障功能,导致细菌进入血液.
研究的目的:
- 调查多创伤和创伤后肺炎对肠道上皮质透性的影响.
- 为了描述由此产生的血液微生物组合,并确定潜在的细菌转移.
主要方法:
- 老鼠接受了多创伤 (PT),慢性克制压力 (PT/CS) 的PT,或 Pseudomonas肺炎 (PT + PNA) 的PT,一些组接受了压力和肺炎 (PT/CS + PNA).
- 使用16S rRNA测序分析了全血微生物组.
- 通过血中奥克卢丁和脂聚糖结蛋白水平来评估肠道透性.
主要成果:
- 与对照组相比,PT/CS + PNA组表现出肠道透性增加和克鲁丁水平升高.
- 在PT + PNA和PT / CS + PNA组的血液中检测到细菌,但在天真,PT或PT / CS组中没有.
- 在第二天,PT/CS+PNA血液微生物组显示链球菌在PT+PNA上占主导地位. 雌性老鼠比雄性老鼠有更高的葡萄球菌和链球菌的丰富性.
结论:
- 伤害后肺炎的多部门创伤增加了肠道的透性,并导致细菌血症.
- 一个独特的血液微生物组在创伤后发展为败血症,显示出明显的基于性别的差异.
- 这些发现凸显了伤害后败血症在严重创伤结果中的临床重要性.
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