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Updated: Jun 15, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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血小板激活因子 (PAF) 促进瘤内的免疫抑制性中性粒细胞分化

Ankit Dahal1, Yeonsun Hong1, Jocelyn S Mathew1

  • 1Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY.

Proceedings of the National Academy of Sciences of the United States of America
|August 23, 2024
PubMed
概括

瘤细胞释放脂质媒介物,如血小板激活因子 (PAF),这些细胞将中性粒细胞转化为免疫抑制性髓质衍生抑制细胞 (MDSC). 这一发现为癌症免疫治疗提供了一个新的目标,通过阻断这种由脂质驱动的分化途径.

关键词:
癌症 癌症 癌症 癌症在MDSC中,MDSC是MDSC.骨髓状细胞是骨髓状细胞.作为一个中性恋者.瘤微环境是一个微环境.

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