在周期性刺激下,真核生物化学反应显示出时间梯度依赖.
Richa Karmakar1, Aravind Karanam1, Man-Ho Tang1
1Department of Physics, <a href="https://ror.org/0168r3w48">University of California, San Diego</a>, La Jolla, California 92093, USA.
Physical review letters
|August 23, 2024
概括
社会性虫细胞在多次接触这些信号后,提高了它们检测化学信号 (循环腺单酸盐) 的能力. 这种增强的化学反应,或细胞运动,通过快速移动的信号观察到,并表明一种形式的细胞记忆.
科学领域:
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
- 发育生物学是发展生物学.
背景情况:
- 社会性虫Dictyostelium discoideum使用循环腺单酸盐 (cAMP) 作为一种化学信使.
- 营养缺乏会触发cAMP的合成和分泌,导致细胞聚合.
- 周期性波的cAMP指导细胞运动通过化学反应.
研究的目的:
- 为了研究单个Dictyostelium discoideum细胞对重复的cAMP波暴露的化学反应.
- 了解细胞记忆如何影响化学反应对周期信号的反应.
- 模拟增强化疗能力的潜在机制.
主要方法:
- 使用微流体装置产生可控的cAMP波.
- 观察并分析了个体细胞对不同波频的化学反应.
- 开发并应用一个计算模型 (局部激发-全球抑制) 来解释实验数据.
主要成果:
- 细胞化学反应能力随着反复暴露于快速移动的cAMP波 (短期) 的增加.
- 这种化学反应的增强对于缓慢移动的波 (大周期) 没有显著意义.
- 实验数据与包含由时间cAMP梯度激活的缓慢上升和衰变组件的模型保持一致.
结论:
- 迪西奥斯蒂细胞表现出一种形式的记忆,增强化学反应,以响应周期性cAMP信号.
- 这种增强的化学反应有利于向信号中心的有效聚合.
- 这些发现提供了关于细胞适应和集体行为的洞察力,以响应环境线索.
相关概念视频
01:21Chemotaxis and Direction of Cell Migration
3.3K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.3K
01:13Actin Polymerization and Cell Motility
5.2K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.2K