相关实验视频

Updated: Jun 15, 2025

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

跨性别患者和性别肯定激素疗法通过中年期

Jaya M Mehta¹, Sarah Kanell², Charlie E A Borowicz³

¹Primary Care Institute, Allegheny Health Network, Pittsburgh, PA, United States of America; Allegheny General Hospital Internal Medicine, Allegheny Health Network, Pittsburgh, PA, United States of America.

|August 23, 2024

概括

经历更年期过渡的变性人需要更多关于性别肯定激素治疗 (GAHT) 风险和益处的研究. 目前的指南缺乏关于跨性别男性 (AFAB) 和女性 (AMAB) 的中年数据.

科学领域:

内分泌学在内分泌学.
跨性别者健康跨性别者健康
绝经研究绝经研究

背景情况:

更年期涉及 cisgender 女人的显著的荷尔蒙和生理变化.
跨性别人口的中年健康状况,特别是关于性别肯定激素治疗 (GAHT) 的健康状况,是研究不足的.
现有的指南缺乏在中年继续高血压治疗的具体建议.

研究的目的:

突出缺乏研究的更年期过渡和中年健康在跨性别人士在GAHT.
确定需要基于证据的指导意见,以持续GAHT到中年.
强调进一步研究对风险评估和管理的重要性.

主要方法:

对中年跨性别人群中GAHT现有文献的综述.
关于与GAHT相关的健康风险的队列和横截面研究的分析.
综合当前的临床实践和指南限制.

主要成果:

有限的数据存在于持续GAHT的安全性和有效性通过中年跨性别个人.
一些研究表明,跨性别女性 (AMAB) 在GAHT上可能会增加心血管事件 (VTE,中风,心肌梗塞) 的风险.
接受丸激素治疗的跨性别男性 (AFAB) 的心血管和骨健康风险尚未确定.

结论:

进一步的研究至关重要,以了解继续GAHT中年男性和女性的风险和益处.
需要基于证据的指导方针,以适当监测和风险管理跨性别人士在中年期间的GAHT.
由于缺乏可靠的数据,患者偏好和临床医生的指导目前为GAHT延续的决定提供了信息.

关键词:

性别肯定激素治疗的性别.更年期绝经绝经中年的人生.变性人和性别多样性

更多相关视频

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

Published on: February 12, 2018

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids

Published on: August 16, 2024

相关概念视频

Menopause

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...

Signs of Puberty

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...

Major Hormones and Their Functions

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...

Gonadal and Placental Hormones

Gonadal and Placental Hormones

The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

Forced Transdifferentiation

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...