新生儿球功能和妊娠期的颗粒物空气污染.
Leen Rasking1, Thessa Van Pee1, Maartje Vangeneugden1
1Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
EBioMedicine
|August 23, 2024
概括
怀孕期间暴露于空气污染颗粒物,特别是在27周后,可能会影响新生儿的功能. 这一发现突显了暴露在空气污染物如黑碳和细颗粒物中的婴儿的潜在长期健康影响.
科学领域:
- 环境健康 环境健康
- 儿科脏病学 儿科脏病学
- 健康和疾病的发育起源 (DOHaD)
背景情况:
- 子数与长期健康结果有关.
- 孕期暴露于环境因素可能会影响胎儿的发育.
- 微粒空气污染是一种广泛的环境暴露,具有潜在的健康后果.
研究的目的:
- 调查新生儿在孕期暴露于微粒空气污染和带血中cystatin C水平之间的关联.
- 评估带血中囊素C作为与空气污染相关的出生时球体健康的标志物.
- 探索不同孕期对这种关联的影响.
主要方法:
- 利用了来自ENVIRONAGE队列的数据,包括1484对母婴.
- 测量了带血中囊素C水平,作为质细胞功能指标.
- 采用多重线性回归和分布式滞后模型来分析粒子空气污染 (黑碳和PM2.5) 和囊素C水平之间的暴露-反应关系.
主要成果:
- 妊娠期间对黑碳 (BC) 和细颗粒物 (PM2.5) 的暴露增加与更高的带血液中酸C水平有关.
- 在BC暴露的0.5μg/m3增加与cystatin C的0.04 mg/L增加相关.
- 暴露在PM2.5中的5μg/m3的增加与cystatin C的0.07 mg/L的增加相关.
- 观察到最强烈的关联是怀孕第三个三个月期间的暴露.
结论:
- 在整个怀孕期间,特别是从第三季度开始,暴露于空气污染颗粒物可能会对新生儿的功能产生不利影响.
- 提升的囊素C水平表明,可能会对出生时的球体健康产生影响.
- 这些发现强调了减轻空气污染的重要性,以保护婴儿脏健康并可能预防未来的健康问题.
相关概念视频
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Pathophysiology of Diabetes
908
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
908
Glomerular Filtration Rate and its Regulation
2.4K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
2.4K
Glomerular Filtration
1.2K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
1.2K
Glomerular Filtration: Net Filtration Pressure
2.0K
Glomerular filtration, a key process in the kidneys, is regulated by three main pressures: Glomerular blood hydrostatic pressure (GBHP), Capsular hydrostatic pressure (CHP), and Blood colloid osmotic pressure (BCOP).
GBHP, with an average value of 55 mmHg, promotes filtration by pushing water and solutes through the filtration membrane. This is balanced by two opposing forces: CHP, a "back pressure" exerted against the filtration membrane by fluid already in the capsular space and renal...
GBHP, with an average value of 55 mmHg, promotes filtration by pushing water and solutes through the filtration membrane. This is balanced by two opposing forces: CHP, a "back pressure" exerted against the filtration membrane by fluid already in the capsular space and renal...
2.0K
Renal Corpuscle
1.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.8K


