在产前乳牛的粘膜免疫反应
Victor S Cortese1, Amelia Woolums2, Merrilee Thoresen2
1Cortese Veterinary Consulting LLC, 10910 Rock Valley Court, Louisville, KY 40241, USA.
Veterinary microbiology
|August 23, 2024
概括
产期荷尔斯坦牛保持完整的粘膜免疫反应,不受鼻内修饰活病毒疫苗接种或基因型的影响. 免疫反应,包括干扰素β和IgA,在分娩后显示出显著的时间依赖的变化.
科学领域:
- 兽医免疫学 兽医免疫学
- 牛的健康问题
- 粘膜免疫力 粘膜免疫力
背景情况:
- 产前期对于牛的健康至关重要.
- 在这个阶段经常报告系统性免疫抑制.
- 粘膜免疫在围产牛中的作用需要进一步研究.
研究的目的:
- 评估周围部分荷尔斯坦牛的粘膜免疫反应.
- 评估鼻内修饰活病毒 (MLV) 疫苗对粘膜免疫的影响.
- 探索基因型特异性与周围部分免疫反应的关系.
主要方法:
- 随机对照试验,使用80头荷尔斯坦牛.
- 在分娩前,分娩后,或两个时间点内注射鼻腔MLV疫苗.
- 测量鼻腔和血清免疫标记物 (IFN-β,IFN-gamma,IgA,SN标位) 和基因定型.
主要成果:
- 疫苗接种时间对整体免疫反应没有显著影响.
- 在所有接种疫苗的群体中,在接种疫苗后观察到数量上升的IFN-马.
- 在分娩后,鼻子IgA和IFN-β的显著时间依赖性增加.
- 没有发现显著的基因型-免疫反应关系.
结论:
- 在围产期期间,牛粘膜免疫反应保持完整.
- 鼻内MLV疫苗接种没有显著改变周周粘膜免疫力.
- 在这项研究中,基因型似乎没有影响周周免疫反应.
相关概念视频
Development of Immunocompetence
295
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
295
Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K


