Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

2.8K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.8K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

[Forensic Clinical Identification of Aortic Dissection Complicated with Delayed Intestinal Rupture： A Case Report].

Fa yi xue za zhi·2026
Same author

Measuring the exposome: a practical guide for using wearable passive samplers to assess environmental influences.

Exposome·2026
Same author

Moxibustion Modulates ALOX15-Mediated Lipid Peroxidation to Inhibit Ferroptosis in Synovial Inflammatory Injury of Rheumatoid Arthritis.

Mediators of inflammation·2026
Same author

Prediction of Coal Spontaneous Combustion Risk under Poor Oxygen Concentration Based on Fuzzy Clustering and Lattice Tightness.

ACS omega·2026
Same author

Emulating the gingival-tooth interface during bacterial, fungal, and viral infection in a microphysiological model of the human oral cavity.

bioRxiv : the preprint server for biology·2026
Same author

Assessment and spatial characterization of ground-level ozone exposure using a low-cost sensor network.

Environmental pollution (Barking, Essex : 1987)·2026

相关实验视频

Updated: Jun 15, 2025

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip
09:46

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

1.7K

基于人体细胞的体外模型:它们能做什么,有什么局限性?

Matthias P Lutolf, Milica Radisic, Jeffrey Beekman

    Cell
    |August 23, 2024
    PubMed
    概括

    基于体外人体细胞的模型是有价值的研究工具,但理解它们的具体用途和局限性是关键. 这项研究探讨了研究人员如何定义和改进这些基本生物模型的有用性.

    更多相关视频

    Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
    10:24

    Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

    Published on: July 4, 2018

    11.6K
    Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
    07:23

    Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications

    Published on: October 20, 2023

    1.3K

    相关实验视频

    Last Updated: Jun 15, 2025

    Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip
    09:46

    Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

    Published on: February 17, 2023

    1.7K
    Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
    10:24

    Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

    Published on: July 4, 2018

    11.6K
    Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
    07:23

    Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications

    Published on: October 20, 2023

    1.3K

    科学领域:

    • 生物医学研究
    • 细胞生物学
    • 药物发现

    背景情况:

    • 在科学研究中广泛使用基于人体细胞的体外模型.
    • 这些模型的实用性经常受到争议,需要定义它们的具体应用和局限性.

    研究的目的:

    • 调查研究人员如何确定体外基于人类细胞的模型的有用性.
    • 确定提高这些模型的效用策略.
    • 了解目前基于细胞的模型的感知限制.

    主要方法:

    • 在实验室中使用基于人类细胞的模型的研究人员的调查.
    • 对模型实用性,改进和局限性的响应进行定性分析.

    主要成果:

    • 研究人员根据生物问题的相关性和预测能力来定义模型的有用性.
    • 改进建议包括标准化,更好的表征和多组数据的整合.
    • 关键的局限性包括缺乏生理相关性和模型间的可变性.

    结论:

    • 定义和增强基于人体细胞的实验模型的实用性需要清楚地了解它们的优点和缺点.
    • 通过方法进步解决这些局限性将有助于它们在生物医学研究和药物开发中的应用.