基因组辅导体HIRA,前列细胞白血病蛋白和p62/SQSTM1协调调节细胞衰老期间的炎症

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Updated: Jun 15, 2025

Techniques to Induce and Quantify Cellular Senescence
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Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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Nirmalya Dasgupta1, Xue Lei1, Christina Huan Shi1

  • 1Sanford Burnham Prebys Medical Discovery Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA.

Molecular cell
|August 23, 2024
PubMed
概括

细胞衰老,衰老的原因,涉及一个炎症分泌表型 (SASP). 研究人员发现,HIRA和PML蛋白对SASP至关重要,通过一种涉及细胞质色素碎片和cGAS-STING信号级联的新途径起作用.

关键词:
在CCF中,我们可以使用CCF.这就是HIRA的意义.通过NF-κB路径.这是PML的PML.PML 的 NBs 是 PML 的 NBs.在 SASP 找 SASPcGAS-STING信号传输系统提供信号.p62/SQSTM 公司衰老是一种老化.

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