与人口对照相比,时间趋势和过度死亡率在第一次肺栓塞或深静脉血栓形成后
Katarina Glise Sandblad1,2, Carl Johan Svensson3,4, Kristina Svennerholm3,4
1Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Thrombosis and haemostasis
|August 23, 2024
概括
肺栓塞 (PE) 和深静脉血栓 (DVT) 死亡率的时间趋势显示整体下降,与一般人口的趋势并行. 然而,在没有癌症的PE患者中,多余死亡率下降,而服用抗凝血药物患者的1年多余死亡率增加.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 流行病学 流行病学
背景情况:
- 与普通人群相比,关于肺栓塞 (PE) 和深静脉血栓 (DVT) 的时间死亡趋势的数据有限.
- 了解这些趋势对于评估不断变化的医疗实践和患者治疗结果的影响至关重要.
研究的目的:
- 调查PE和DVT患者30天和1年死亡率的时间趋势.
- 为了比较这些患者群体的过度死亡率趋势与匹配的人口对照.
主要方法:
- 从2006年到2018年,一项全国性的瑞典注册研究包括68960例PE和70949例DVT病例.
- 用Poisson和Cox回归模型分析死亡率趋势和过度死亡率,显著程度为0.001.
主要成果:
- 对于PE和DVT病例,整体30天和1年死亡率下降.
- 没有癌症的PE患者的过度死亡率显示,30天死亡率显著下降.
- 活着接受抗凝药治疗的PE患者显示,超过1年死亡率的增加.
结论:
- 虽然PE和DVT的总体死亡率有所改善,但特定子组在过度死亡率方面表现出不同的趋势.
- 这些发现强调了对高风险PE患者群体的持续监测和有针对性的干预措施的需要,特别是那些长期服用抗凝药的人群.
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