超声波脉冲的重复频率优先激活不同的神经元群体,独立于细胞类型
Jack Sherman1,2, Emma Bortz1, Erynne San Antonio1
1Department of Biomedical Engineering, Boston University, Boston, MA, United States of America.
Journal of neural engineering
|August 23, 2024
概括
跨超声波的不同脉冲重复频率 (PRF) 可以选择性地激活清醒大脑中的不同神经元群体. 这一发现表明,通过结合生理PRFs,可以改善神经调节的潜力.
科学领域:
- 神经科学是一个神经科学.
- 生物物理学的生物物理.
- 神经调节是一种神经调节.
背景情况:
- 超超声波 (US) 刺激是一种外部输入,基于内在特性影响神经元反应.
- 神经元表现出频率偏好,通常限于几百赫兹.
- 以前的美国研究经常使用超生理脉冲重复频率 (PRF),使生理PRF的影响不清楚.
研究的目的:
- 调查跨脑US的不同生理PRF是否可以在清醒的哺乳动物大脑中激活不同的神经元群体.
- 在同一神经元内的各种PRF中比较唤起的神经元反应.
- 探索细胞类型依赖的效应和机械敏感通道表达.
主要方法:
- 记录了小鼠运动皮质神经元对US的细胞反应,其脉冲频率为10,40和140Hz.
- 在单个神经元中比较PRFs之间的唤起反应.
- 用RNA测序数据对神经元进行了分类 (快速激增的内部神经元与假定的激发性神经元),并分析了机械敏感通道表达.
主要成果:
- 许多神经元显示单个PRF的优先激活,不同的PRF参与不同的神经元群体.
- 美国引起的反应模仿了自然的尖端活动,表明神经元内在活动增加.
- 在抑制性和刺激性神经元中,唤起的反应是相似的,这表明细胞类型独立的机敏通道表达驱动了反应异质性.
结论:
- 跨骨US可以通过调节PRF.选择性地激活不同的神经元子组.
- 生理PRF提供了针对性神经调节的可行方法.
- 结合生理 PRF 具有增强神经调节效能的潜力.
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