抗微生物药物耐药性的特征 在修正后从菜和土壤中分离出来的肠道细菌
E Anedda1, D Ekhlas2, E Alexa3
1Antimicrobial Resistance and Microbial Ecology Group, School of Medicine, University of Galway, Ireland; Food Safety Department, Teagasc Food Research Centre Ashtown, Dublin, Ireland.
Environmental pollution (Barking, Essex : 1987)
|August 23, 2024
概括
修正案没有显著影响土壤或菜中的抗菌素耐药性肠道细菌. 这项研究研究了食品生产环境中的耐药细菌,发现Serratia fonticola占主导地位,与含量没有明确的联系.
科学领域:
- 环境微生物学环境微生物学
- 食品安全 食品安全
- 抗微生物耐药性 (AMR) 是一种
背景情况:
- 抗微生物耐药性细菌是食品生产中的一个问题.
- 重金属可以影响抗菌素耐药性 (AMR) 的传播.
- 在农业土壤中AMR传播中的作用尚未完全理解.
研究的目的:
- 调查土壤和菜中抗菌素耐药性肠道细菌的存在和特征.
- 为了确定修正是否会影响AMR Enterobacterales的流行.
- 为了确定耐药性基因及其与和重金属载体的关联.
主要方法:
- 从经过修改和未经修改的农业用地 (土壤和菜) 采样.
- 基于培养的特定耐药肠道细菌的检测 (ESBL,卡巴胺,抗西普洛素).
- 孤立的全基因组测序 (WGS) 和感应合的等离子体原子发射光谱学 (ICP-AES) 用于量化.
主要成果:
- 20个抗微生物耐药的肠道细菌分离物被回收 (8个土壤,12个菜).
- 塞拉蒂亚fonticola是主要的物种,其他物种包括大肠杆菌和Citrobacter freundii.
- 世界海洋学会证实了耐药性基因,包括ESBL生产的BlaFONA,并确定了耐药性和多种药物排泄基因.
结论:
- 修正似乎没有影响研究的土壤和菜样本中AMR肠杆菌的存在或特征.
- 观察到抗微生物药物和重金属耐药性基因的共同选择.
- 需要进一步的研究,以充分阐明重金属和农业环境中的抗药性之间的复杂相互作用.
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