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Updated: Jun 15, 2025

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通过COSMO-RS进行药物聚合物兼容性预测

Alex Mathers1, Michal Fulem1

  • 1Department of Physical Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic.

International journal of pharmaceutics
|August 23, 2024
PubMed
概括

真实溶剂的导体样选模型 (COSMO-RS) 准确地预测了聚烯利 (PVP) K12 活性药物成分 (API) 的固体液体平衡 (SLE) 曲线. 建议采用传统方法,而不是加快方法,以获得可靠的API-聚合物兼容性选.

关键词:
无形固体的分散性固体.在COSMO-RS的基础上,药物聚合物 药物聚合物阶段图 阶段图固体液体平衡的情况可溶性 可溶性 溶性

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