在ENDEA病例控制研究中, perfluoroalkyl物质 (PFAS) 暴露与子宫内膜异位症之间存在关联
Teresa de Haro-Romero1, Francisco M Peinado2, Fernando Vela-Soria1
1Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18016 Granada, Spain; Clinical Laboratory Management Unit, San Cecilio University Hospital, 18016 Granada, Spain.
The Science of the total environment
|August 23, 2024
概括
暴露于某些 perfluoroalkyl 物质 (PFAS) 可能会增加子宫内膜异位症的风险. 具体来说, perfluorotridecanoic acid (PFTrDA) 显示出与女性子宫内膜异位症更高的几率有显著的关联.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 毒理学 毒理学 毒理学
背景情况:
- perfluoroalkyl物质 (PFAS) 是消费品和饮用水中广泛存在的环境污染物.
- 以前的研究将PFAS暴露与女性不良生殖结果联系起来.
- 关于PFAS暴露与子宫内膜异位症风险之间的关联,人类数据有限.
研究的目的:
- 调查单独或混合的特定PFAS的血度与子宫内膜异位症风险之间的关系.
- 评估暴露于各种PFAS的生育年龄妇女子宫内膜异位症的几率.
主要方法:
- 一项涉及42名子宫内膜异位症患者和90名控制者的病例控制研究,在2018年至2020年期间招募.
- 通过腹腔镜检查和组织学分析确认了子宫内膜异位症的诊断.
- 在血样本中量化10个PFAS,使用后勤回归和量化g计算进行混合物分析.
主要成果:
- perfluorotridecanoic 酸 (PFTrDA) 与子宫内膜异位症的几率增加有显著的关联 (OR=1.74).
- perfluorohexane sulfonate (PFHxS) 和总结的短链PFAS (SC) 显示出边际显著的关联.
- 整体PFAS混合物效应在统计学上并不显著,但PFNA,PFHxS和PFTrDA是主要的贡献者.
结论:
- 研究结果表明,某些PFAS,如PFTrDA,可能会增加子宫内膜异位症的风险.
- 该研究强调,由于样本规模较小,需要进行进一步研究.
- 结果表明潜在的环境因素对子宫内膜异位症的发病有所贡献.
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