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含有三甘油的奇多纳米凝在伤口愈合过程中加速血管生成

Khatereh Asadi¹, Negar Azarpira², Reza Heidari³

¹Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medical Nanotechnology, School of Advanced Medical Science and Technology, Shiraz University of Medical Sciences, Shiraz, Iran; Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran.

International journal of biological macromolecules

|August 23, 2024

概括

含有三甘油的奇多纳米凝通过促进原蛋白和血管生成,同时减少炎症,加速伤口愈合. 这种局部治疗有望改善伤口修复和减少痕.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
伤口治愈研究研究伤口治愈研究

背景情况:

三甘油 (TNG) 具有有利于伤口愈合的血管新生,抗菌和抗氧化特性.
由于并发症和短的氧化 (NO) 半衰期,TNG的临床使用受到阻碍.
酸盐纳米凝提供了一个潜在的输送系统,以克服TNG的局限性.

研究的目的:

开发和表征三二甲酸甘油载荷奇托纳米凝 (TNG-Ngs).
评估TNG-Ngs在伤口愈合应用中的体外和体内疗效.
评估TNG-Ngs作为皮肤伤口修复局部治疗的潜力.

主要方法:

制备和TNG-Ngs. 的生理化学特征.
使用HUVECs进行体外生物相容性和痕测试.
在全厚皮肤伤口模型上进行体外评估.
组织病理学和免疫组织化学分析 (α-SMA,CD31).

主要成果:

TNG-Ngs表现出有利的颗粒大小和分布,载荷能力为70.2%,封装效率为2.1%.
增强的HUVEC迁移在没有观察到的细胞毒性 in vitro.
实体研究显示,伤口完全关闭,改善皮肤成分形成,减少痕,增强颗粒组织,增加原沉积.
显著上调α-SMA和CD31的表达,表明增强的血管生成和组织重塑.

结论:

通过促进原沉积和血管新生活性,TNG-Ngs有效地加速伤口愈合.
纳米凝配方可减少炎症并改善伤口区域的血管化.
TNG-Ngs代表了一种有前途且有效的局部治疗方法,用于伤口愈合.

关键词:

血管新生的产生.基托桑是一种酸盐.纳米凝是一种纳米凝.自然聚合物的天然聚合物.三基甘油是三基甘油中的一种.伤口愈合伤口愈合

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